One problem related to check engine light on has been reported for the 2006 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Honda Odyssey based on all problems reported for the 2006 Odyssey.
On my way to work on January 14, 2014, as I was getting up to speed (from 0 to 20), the engine revved around 2000 rpm, the transmission would not engage 2nd gear. I backed off the gas pedal and the transmission engaged. The check engine light lit up and I drove it to a Honda dealership. The service department said that their diagnostic revealed an internal issue with the transmission and would need replacement. I have owned 7 Hondas since 1983, and I have never had this type of problem. The van is at a local transmission shop rebuilding the transmission for $1500, Honda wanted $5300. The van has been well maintained over the years and I'm very surprised that the transmission would go at 141,000 miles, but transmission issues appears to be a problem with the Odyssey lineup over the years. Unfortunately, I was not made aware of these issues prior to purchase. Disappointing.