One problem related to automatic transmission has been reported for the 2010 Mercedes Benz E350. The most recently reported issues are listed below.
2010 mercedes 350 e class 4 matic drive system defaults into second gear after each start cycle. This results in a compromise of torque when pulling into traffic whole fully loaded on a hot day.
| Power Train problems | |
| Differential Unit problems | |
| Automatic Transmission problems | |
| Transmission Gear Indicator problems |