One problem related to differential unit has been reported for the 2010 Mercedes Benz E350. The most recently reported issues are listed below.
Rear differential pinion bearing. The rear differential is making a howling and loud noise. The car only had about 60k miles and the bearing failed. This is a known issue for this model and other mercedes models as well. I got quoted around $3000 to fix this. This should not be an issue on a $65,000 car at this many miles. Mercedes benz needs to do a recall on the red differential since they fail at a very low mileage.
| Power Train problems | |
| Differential Unit problems | |
| Automatic Transmission problems | |
| Transmission Gear Indicator problems |