Two problems related to transmission failure have been reported for the 1999 Chevrolet S10. The most recently reported issues are listed below.
General motors transmission failure. 4l60e transmission started having trouble before 50,000 miles. In the shop now.
Wife was driving the vehicle and transmission failed without warning (disengaged and lost power). This happened on a busy highway and nearly caused an accident and fatalities. This happened on a 2 year old vehicle with 70,000 miles that had been serviced regularly.