One problem related to transmission noise has been reported for the 1999 Chevrolet S10. The most recently reported issues are listed below.
I have a 99 s-1o extreme I have had it for about 3 years now. It only has 43000 miles on it and already the transmission is starting to fail. I have started getting a humming noise out of it. I have replaced the filter and fluid, but it still remains. I was at some message boards tonight on the internet and there are hundreds of complaints about the 4l60 transmission that gm uses in a great deal of their vehicles and they aren't doing anything for these people who are paying thousands of dollars to have them fixed.