One problem related to engine knocking noise has been reported for the 2006 Chrysler 300. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Chrysler 300 based on all problems reported for the 2006 300.
Engine begin making a loud knocking noise steering wheel locked up could not turn or do anything with the car. I immediately put hazards on, noise stopped car began to slow down until it completely stopped. Car would not start back . Later found out it was do to oil sludge built up. Oil light never came on when the oil was out causing engine failure.