One problem related to axle shaft seal has been reported for the 2000 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford F-150 based on all problems reported for the 2000 F-150.
Had four new tires placed on my f150. When the right rear tire was removed, the tech noticed differential fluid and said that the rear right axle seal was blown. Parts required to fix are the bearings, brake reassembly, new rear axle, and emergency brake pads.