One problem related to differential unit has been reported for the 2000 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford F-150 based on all problems reported for the 2000 F-150.
The rear end bearings were defective and may cause the driveshaft to drop out of vehicle. One could hear a rumble/whining noise up to 40 yards away. The rear end was overhauled.