Ford F-150 owners have reported 2 problems related to power door locks not working (under the electrical system category). The most recently reported issues are listed below. Also please check out the statistics and reliability analysis of Ford F-150 based on all problems reported for the F-150.
Power door locks would not open. Had to use key to enter vehicle and then physically pull up door locks to open doors. Only happened when temp was freezing twice so far when vehicle was parked outside.
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Cold morning and the power door locks would not unlock with the remote or the key in the drivers door, after climbing in the back door to open the front neither the rear door or the front door would latch when the door was closed. Extremely unsafe, could not drive the truck to work because the doors would not latch shut.