One problem related to engine noise has been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
Driving to work yesterday evening I stopped to gas up. After fueling the truck I started the engine and heard a loud pop followed by loud engine noise. I shut down the engine to investigate and found the spark plug from the second cylinder on the passenger side ejected destroying the coil in the process. I have yet to repair the problem and have concerns that it will happen again.