Five problems related to brake hoses, lines/piping, and fittings have been reported for the 2001 Ford F-250. The most recently reported issues are listed below.
Brake line to the rear brakes ruptured due to extreme corrosion inside the frame this failure resulted in the loss of braking/stopping power without any warning. The line was replaced.
A rear brake line on my 2001 Ford F-250 super duty truck rusted through, causing a loss of brake fluid and braking ability. I replaced the brake line with a part from Ford, but Ford seemed uninterested in addressing this failure, which I had never heard of happening before. I still have the old part.
There is a brake line to the rear wheels located roughly above the differential. That line is in close proximity to another cable (maybe the emergency brake cable) and the brake line and cable are rubbing together. The brake line is very worn in that area from contact with the cable. It looks to be worn to a point that would be very close to the "core"of the brake line. Of course excess pressure or further wear could cause a failure of that line and therefore loss of rear braking.
The left rear brake line failed. The line was made of rubber. As a result, when the brakes were applied, the driver's foot went to the floor and the driver had to down shift to stop the vehicle.
The clutch hose hydraulic line the runs from the master cylinder to the clutch slave cylinder melted across the exhaust manifold.