One problem related to brakes failed has been reported for the 2001 Ford F-250. The most recently reported issues are listed below.
Complete brake failure has occurred. The night I brought it home then two weeks later the same thing. Went to apply brakes and pedal went to floor. I did hear a noise coming from under the hood while it occured. After I coasted to stop. Brakes were find again. Very bizzarre!.