One problem related to engine head gasket failure has been reported for the 2006 Ford F-250. The most recently reported issues are listed below.
The contact owns a 2006 Ford F-250 sd. The contact stated that the vehicle would over heat and smoke would come from underneath the hood. The dealer diagnosed that the contact needed to replace the head gasket. The manufacturer was also notified of the failure. The vehicle was not repaired. The failure mileage was 125,000 and the current mileage was 130,000.