One problem related to manual transmission column shift has been reported for the 2005 Nissan Titan. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2005 Nissan Titan based on all problems reported for the 2005 Titan.
Column shifter causes damage to wiring harness of the manual mode transmission button. When shifting vehicle into drive, column hits wiring harness, and over time causes wiring to the transmission manual mode button to break. Once this breaks, there is no means to down shift vehicle, causing a hazard especially when traveling roads where there are elevation changes. Was able to determine the cause of the manual mode button failure by researching Nissan Titan forums (club Titan and Titan talk). Upon removing steering column shroud immediately noticed chaffing of the wiring harness, and the broken wire. Contacted Nissan, was given file number 6550464, Nissan was not concerned with this issue due to the age (currently 4 years) of the vehicle.