One problem related to differential unit has been reported for the 2001 Chevrolet S10. The most recently reported issues are listed below.
During 41,000 service observed rear pinion seal leaking, after 3 attempts to get the correct seal, finally found the correct one. Parts stores only show 3 different seals for a 2001 s-10 pickup w/ 4. 3l engine and automatic transmission. Had to go to 2003 s-10 pickup to find the correct seal.