One problem related to automatic transmission cooler has been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
A company vehicle caught fire when using, vehicle had been examined, and fire was the result of transmission lines being positioned too close to exhaust system, a heat producing source. Temperature that day was approximately 75-80 degrees. Manufacturer not willing to take any responsibility, they are stating there was no manufacturing defects that caused fire.