Four problems related to driveshaft have been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
Front hubs on 4wd Ford F-250 pickup were stuck in locked, even though set to automatic. Caused failure of cv joint on front drive shaft, which resulted in crack case and transmission exploding (literally, as in parts flying all over I-80). Transmission shop owner (action transmission, rock springs, wy) indicated he's seen same occur before. One part dented support on pontoon boat being towed -- if not there, could have gone through someone's windshield. A very dangerous failure, in my opinion. I have kept and photographed the parts replaced by shop (except what was left of the transmission, which was required to avoid core charge) as well as several pieces I picked up off hightway. The hubs had problems in the past and were replaced less than 11,000 miles before incident, yet were outside Fords 12-month "warranty" period. They have refused to provide any financial assistance with repairs. Ford dealer in rock springs had several week backlog on transmission work so I had it repaired elsewhere ($5,818).
While accelerating and stopping there is a clunk and you can feel it under the truck. The dealer suggested it was the brakes. I had the brakes changed and the rotors and drums checked but it is still having the problem. I recently visited the Ford -trucks. Com site to find several cases of this and it apparently is due to an improperly greased drive shaft at the rear bearing. This is a problem that Ford should correct due to their negligence in improperly greasing the joint.
Vehicle vibrated uncontrollably at various speeds. Dealer has replaced driveshaft and tires, but vehicle continued to vibrate. Manufacturer has been notified.
Extreme vibration in rear driveshaft when towing in low gear. Vibration is daily.