One problem related to engine cooling system has been reported for the 2010 Ford F-250. The most recently reported issues are listed below.
Radiator leaking. Fourth radiator now being installed. Ford motor CO told dealer to pull the water pump to see if the plate showed cavatation. Found the water pump housing had faulty machining( porosity). Radiators replaced at 28,000-53,000 and now at 100,000.