One problem related to manifold/header/muffler/tail pipe has been reported for the 2010 Ford F-250. The most recently reported issues are listed below.
Since I have owned this truck from 2010 to current I have had problems with the exhaust manifolds and a transmission overflow relief valve. The exhaust manifolds keep popping the studs which allows fumes inside the truck upon a $2000. 00 bill every time. . . This issue could cause the whole exhaust system to fall right out from under the truck while driving. The other issue is the trans overflow. . . . Everytime it happens it spits the fluid out all over the exhaust which causes a fire everytime. I have been reporting these problems since I have purchased the truck. These problems need to be adressed before someone gets hurt or worse.