Two problems related to radiator have been reported for the 2010 Ford F-250. The most recently reported issues are listed below.
Hose to radiator leaking, took to Ford dealer, they said new hoses and needed a new radiator. Said it was still under Ford extended warranty. Ford warranty denied the new radiator and hoses saying that the hose leak cracked the radiator and that was the owners fault. Truck has just under 44k miles and is garaged and well taken care of. What good is an extended warranty, first. And second, why should a radiator go bad in short time. Quote for job was over $2000. 00.
Radiator leak and exhaust manifold bolts. I just bought a used Ford f250 diesel fx4 lariat. Nice truck but nothing but problems so far. It had 128k on it. Just noticed today that every time I fill the resivoir it leaks out. Looks like the radiator leaking where the plastic and aluminum meet. Over a thousand installed. Then the whine that was supposed to be a belt ended up being broke off exhaust bolts on manifold. 16 hrs at $1300 plus parts maybe another $130. Not happy with this Ford at all. Sad that's what my last four vehicles were.