Two problems related to steering gear box have been reported for the 2000 Ford F-350. The most recently reported issues are listed below.
The steering shaft (power steering gear box output shaft) snapped off while approaching a stop sign at about 35 mph. When this happened the vehicle did stop with no accident. I am in the process of fixing this problem.
2000 f350 4x4 extended cab had steering problems since day one. Truck would wander at all speeds. Dealer finally replaced steering gear box at my request and at my cost and truck now steers as it should. This part should be a warranty part.