One problem related to automatic transmission control module has been reported for the 2000 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Toyota Sienna based on all problems reported for the 2000 Sienna.
Location-parking lot, raining, tires lost traction and accelerator stuck on full, brakes would not function. The vehicle propelled forward glancing off the back of a full sized pickup and deflected into a suburban where it finally stopped. No one was hurt but this situation could have been very serious if anyone had been near because I had very little control(steering only).