One problem related to transmission not engage has been reported for the 2000 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Toyota Sienna based on all problems reported for the 2000 Sienna.
Complete and permanent transmission failure. Vehicle suddenly and permanently lost ability to accelerate/transmission disengaged while traveling on interstate at 65mph. Barely coasted to side of road while trying to avoid traffic bearing down on us (two adults and three small children). We have now discovered that this defect with Siennas, was known as early as June 2000. This defect usually causes complete transmission failure during sustained highway speeds. Toyota was negligent in not warning owners of this extremely hazardous defect. Our vehicle is now about 300 miles from our home, with no fix currently available from Toyota.