One problem related to driveshaft has been reported for the 2000 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Toyota Sienna based on all problems reported for the 2000 Sienna.
To date my Sienna has 25,000 miles on it. It had the torque converter replaced at 200 miles, the battery replaced because it went dead for no apparent reason within a year, the rear struts on the hatch have failed and needed to be replaced, the lights on the console blew out, the tires need to be replaced at 25,000 miles due to being out of alignment, vehicle pulls to left consistently, shakes at speeds over 60 mph, sliding doors consistently stick, pronounced clunk when going in reverse down a slight incline I am sure there is more to come. Dt.