Chevrolet Silverado 2500 owners have reported 1 problem related to power door locks not working (under the electrical system category). The most recently reported issues are listed below. Also please check out the statistics and reliability analysis of Chevrolet Silverado 2500 based on all problems reported for the Silverado 2500.
Power door locks fail to lock or unlock when warm. Door lock actuators have been replaced previously and now again thy are failing. Leaving the door unlocked after remote locking and unable to unlock the door when needed, including in an emergency situation you are stuck inside unless you can reach to manually unlock the door. This is an unsafe condition and should recall these failing actuators just like the failing transmission lines they won't recall them but they did extend a warranty repair for 10 years. Gm do the right thing and issue the same extended repair warranty before someone is killed due to unable to unlock vehicle in an emergency. 66,000 miles and second set of door lock actuators and windows switches. These are possibly failing from all the water the door window seals let inside the doors. Had all the window switches replaced previously as well. Locks sometimes will work once but fail after that, also in a sunny hot day they fail 100% to unlock. Key sets off alarm so you have to unlock via keyfob and then unlock with physical key. Not real convenient. To lock you have to walk around and physically lock each door that failed to lock and then lock with keyfob to set alarm.
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