One problem related to axle shaft seal has been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
Vehicle fails to stop properly when brakes are applied. Would shake and vibrate badly. Took vehicle to dealership, mechanic noticed rotors were warped, which caused the braking problem. Had them replaced after 10,000 miles. Engine stalls and oil leaks from the turbo into the inter cooler. Transmission does not shift. Tires began to bulge out, consumer did not specify kind of tires. Electric window motor failed. Seals are out on the front axles and they were just replaced two months ago. Air filter system is inadaquet for this size of engine and has to be replaced every 2 to 3 thousand miles.