Two problems related to transmission failure have been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
At 85000 miles of very light use my f250 hd model year 2000 with diesel engine had a transmission failure and had to be replaced. If this truck is referred to as a super duty and heavily advertised as such a strong truck why would my transmission fail. Again this truck is used more like a car then a construction vehicle.
Repeated manual transmission failure. Ford replaced my manual transmission on my 2000 f250 under warranty, with about 35,000 miles on it. The transmission again failed with about 84,000 miles on the truck, 49,000 on the transmission, and $4,000 out of my pocket. This truck is well maintained and rarely operated with a load. A second complaint is that I have now taken my truck in for the 100,000 tune up. The dealer informed me the spare tire fell off because the cable holding it broke. The spare tire has never been removed from the truck. This is a serious concern if spare tires are falling off of trucks.