One problem related to differential unit has been reported for the 2005 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2005 Honda Odyssey based on all problems reported for the 2005 Odyssey.
Rebuild transmission due to worn out differential bearings that caused the transmission fluids to break the axel seal and leak a lot of fluid which could of destroyed transmission all together.